Essential for Female Fertility MAPK 3 / 1 ( ERK 1 / 2 ) in Ovarian Granulosa Cells
نویسنده
چکیده
www.sciencemag.org (this information is current as of July 6, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/324/5929/938 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/324/5929/938/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/324/5929/938#related-content http://www.sciencemag.org/cgi/content/full/324/5929/938#otherarticles , 12 of which can be accessed for free: cites 18 articles This article http://www.sciencemag.org/cgi/content/full/324/5929/938#otherarticles 1 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/development Development : subject collections This article appears in the following http://www.sciencemag.org/about/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining
منابع مشابه
Female Fertility MAPK 3 / 1 ( ERK 1 / 2 ) in Ovarian Granulosa Cells
clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): July 19, 2012 www.sciencemag.org (this information is current as of The following resources related to this article are availa...
متن کاملPossible intracellular regulators of female sexual maturation.
Protein kinases, transcription factors and other apoptosis- and proliferation-related proteins can regulate reproduction, but their involvement in sexual maturation remains to be elucidated. The general aim of the in vivo and in vitro experiments with porcine ovarian granulosa cells was to identify possible intracellular regulators of female sexual maturation. For this purpose, proliferation (e...
متن کاملP-111: EGFR, ERK, MEK Genes Expression Level in Cumulus Cells of PCOS Women Compared with Healthy Women
Background Poly cystic ovarian syndrome (PCOS) is known as a common endocrine disorder in women at reproductive ages and may cause developmental abnormality in oocyte. ERK has found as a regulator protein of Gap junctions (GJ) function and the level of exchanges between two neighbors cells, for example oocyte and surrounding cumulus cells (CCs) in the mammalian ovary. Such exchange is essential...
متن کاملLiver receptor homolog 1 is essential for ovulation.
Female fertility requires normal ovarian follicular growth and ovulation. The nuclear receptor liver receptor homolog 1 has been implicated in processes as diverse as bile acid metabolism, steroidogenesis, and cell proliferation. In the ovary, Lrh1 is expressed exclusively in granulosa and luteal cells. Using somatic targeted mutagenesis, we show that mice lacking Lrh1 in granulosa cells are st...
متن کاملOrphan nuclear receptor function in the ovary.
Orphan nuclear receptors such as germ cell nuclear factor (GCNF), steroidogenic factor 1 (SF-1) and liver receptor homolog-1 (LRH-1), are emerging as important ovarian factors in regulating female reproduction. Within the ovary, GCNF (NR6A1) expression is restricted to the oocyte, while SF-1 (NR5A1) is expressed only in the somatic cells, such as granulosa, thecal and luteal cells, and intersti...
متن کامل